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Whether testicular shrinkage is permanent or not depends on the potency of the dosage, and the duration for which steroids have been taken. For instance, dutasteride has a potency of 25 mcg/mL and its duration of use is 3 years. This is very strong and can result in irreversible testicular shrinkage. However, it can be cured by careful dutasteride treatment with vitamin B6 at the recommended dosage, and by dutasteride reduction with other vitamins and minerals, as well as the use of dutasteride and vitamin B6 as a vitamin B supplements. Even low-dose doses of steroids can cause permanent testicular shrinkage. Because the use of drugs like dutasteride is very effective, more research is needed to define effective and appropriate dosage schedules before men with infertility get pregnant. Some men who start testosterone suppression with high doses may be more sensitive to the effects of testosterone supplementation and some may have a longer gestation period than others. Furthermore, the use of high-dose steroids, such as 10 to 50 mg of testosterone in every 7 to 10 hours, may be unnecessary. The bottom line is that for those who need to improve their testicular function, testosterone supplementation is safe, effective and safe to use—with appropriate dosage and dosing schedules, and with careful monitoring. Back to top Article Information Corresponding Author: Michael S. Jorgensen, MD, Department of Urology, New York University School of Medicine, New York City; 212-966-5930. Affiliation: Michael S. Jorgensen, MD, Departments of Urology and Endocrinology, New York University School of Medicine, New York City; 212-966-5930. Accepted for Publication: July 9, 2005. Published Online: November 16, 2005. doi:10.1001/jama.2005.1209. Author Contributions: Drs Jorgensen and Brown had full access to all of the data in the study and take responsibilities for the integrity of the data and the accuracy of the data analysis. Study concept and design: Jorgensen, Brown, and Srivastava. Acquisition of data: Jorgensen, Brown, and Srivastava. Analysis and interpretation of data: Jorgensen, Brown, and Srivastava. Drafting of the manuscript: Brown. Critical revision of the manuscript for important intellectual content: Brown, Jorgensen, Brown, Srivastava, and Srivastava. Statistical analysis: Srivastava. Obtained funding: Jorg Related Article:

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Lyka labs net, buy anabolic steroids in europe
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